Chamois was inhabited starting from the first centuries of the Low Middle Ages when the progressive demographic expansion that followed the year 1000 caused the clearing and the population of large areas, previously uninhabited or exploited only seasonally. As we learn from the testaments of Ebalo Magno of Challant dating back to 1323 and his nephew Ibleto (1405), in the 14th century this town became one of the fiefdoms of the lords of Challant-Montjovet, unlike the other communities in the area that belonged to the lords instead of Challant-Cly, including the current municipality of Antey-Saint-André from which Chamois depended from an ecclesiastical point of view. The son of Ibleto, François, first count of Challant, in 1486 granted to the subjects of the lordship of Châtillon a charter of the franchises in which were also attached Pontey and Chamois itself. Vittoria Solaro della Moretta, wife of François de Challant baron of Chatillon, was remembered in 1691 and in 1691, when the Valle d’Aosta was invaded by the troops of the king of France Louis XIV, he abandoned the castle of Châtillon and with his sons she took refuge in Chamois, where she was welcomed with joy by her subjects who would have hosted her for a long time if the Marquis of La Hoguette, commander of the French army, had not found her and brought her back to Châtillon, where he held her nobly hostage.
In 1681, the bishop of Aosta, Albert-Philibert Bailly, decreed that Chamois become a parish church under the patronage of Saint Pantaleon, detaching its territory from the mother church of Antey-Saint-André. The pre-existing chapel of Corgnolaz was rebuilt and enlarged, and following the construction of the church, Corgnolaz replaced the village of La Ville (or Grand-Ville) as the capital of the community. The territory of Chamois was also aggregated to the district of Cly and in 1751 the Marquis Giacomo Bergera, Baron of Cly, freed it from the residual feudal dues due to him.As early as 1700, a number of public schools were founded in Chamois: in particular, in La Ville, the school for girls was founded by Jean-Jacques Perruquet, from Valtournenche, parish priest of Chamois from 1740 to 1750.In the 19th century, popular education continued to be promoted, so much so that at the beginning of the 1900s, there were four schools in this municipality.